A vacuum regulator (vacuum regulator/valve) maintains a stable, defined negative pressure in a system by means of a spring-loaded/dome-loaded diaphragm that regulates the inflow of ambient air. When the vacuum level falls below the set point, the diaphragm opens the valve and allows air to enter in order to increase the pressure again. In pharmaceutical production, vacuum regulators are used to control pressure during lyophilisation (freeze-drying) and sterile packaging, where precise and stable negative pressure is crucial to product quality. In the food and beverage industry, they are used in vacuum filling systems and concentration processes, and in cleaning equipment for cleanrooms and produced water systems, they are available in versions made from 316L stainless steel with FDA and USP VI-approved seals.